Published on:
    Journal of Cardiovascular Disease Research, 2010; 1(2):64-68
    Review Article | doi:10.4103/0975-3583.64436

    Role of diabetes, hypertension, and cigarette smoking on atherosclerosis


    Ram K. Mathur
    California Department of Public Health, 850 Marina Bay Parkway, Richmond, CA 94804, USA


    Hyperosmolar food causes atherosclerosis. Hyperosmolal food hypothesis encompasses all the factors involved under one heading and, that is, the generation of heat in the body. The involvement of cigarette smoking is obvious. High glycemic index food and diabetes result in high levels of blood glucose, which raises the core body temperature. The ingestion of hyperosmolal salt, glucose, and amino acids singularly or synergistically raise the core body temperature, forcing abdominal aorta to form an insulation wall of fatty material causing atherosclerotic plaques. The osmolarity of food, that is glucose, salt, and amino acids is reduced when water is ingested with food. The incidence of atherosclerosis goes down with increasing intake of water.

    Key words: Atherosclerosis, cigarette smoking, diabetes, hypertension.