Published on:
    Journal of Cardiovascular Disease Research, 2010; 1(2):86-91
    ORIGINAL PAPER | doi:10.4103/0975-3583.64442

    Factor analysis of risk variables associated with metabolic syndrome in adult Asian Indians

    Authors:

    Mithun Das, Susil Pal1, Arnab Ghosh2

    Post Graduate Department of Anthropology, Sree Chaitanya College, Habra, West Bengal,

    1Human Genetic Engineering Research Centre, Calcutta,

    2Biomedical Research Laboratory, Department of Anthropology, Visva Bharati University, Santiniketan, West Bengal, India

    Abstract:

    Background: Several studies hinted about the clustering of risk variables of the metabolic syndrome (MS) and suggested that the underlying genetic polymorphisms could be responsible for the increasing incidence of coronary heart disease (CHD) in people of Indian origin. Therefore, identi cation of the components of the MS along with the genetic factors could be one of the aspects to make an attempt to prevent the increasing incidence of CHD. Materials and Methods: Principal component factor analysis (PCFA) was undertaken to identify the components or factors of the MS among the adult (30 years) Asian Indians living in and around Calcutta, India. The study comprised 350 adult Asian Indians. Anthropometric measurements were taken, and lipid pro les, blood pressure and fasting blood glucose were measured for each participant. Two genetic polymorphisms, namely, angiotensin converting enzyme (ACE) gene polymorphism (insertion/deletion [I/D]) or ACE (I/D) and apolipoproteinE (Hha I) were also studied. Results: PCFA revealed 3 factors that cumulatively explained 65.39% of the observed variance of the MS by measured variables. The 3 factors identi ed were lipids and lipoprotein (Factor 1), centripetal fat and blood pressure (Factor 2), and ACE (I/D) polymorphism with blood pressure (Factor 3). Moreover, the  rst 2 factors, that is, lipids, lipoprotein, centripetal fat, and blood pressures cumulatively explained ~46% (45.94%) of the observed variance of MS in this population. Conclusions: Since more than 1 factor was identi ed for the MS phenotype, more than 1 physiogenetic mechanism could be accounted for MS in the Asian Indian population.

    Key words: Asian Indians, factors, gene polymorphism, metabolic syndrome, obesity.