Published on:
    Journal of Cardiovascular Disease Research, 2010; 1(2):47-49
    Editorial | doi:10.4103/0975-3583.64429

    Genetic testing for channelopathies, more than ten years progress and remaining challenges

    Authors:

    Peng Zhou, Junhua Wang1

    Section on Cardiology, Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA.

    1Department of Cardiology, Air Force General Hospital, PLA, No.30, Fucheng Road, Haidian District, Beijing 100142, China, PRC.

    Abstract:

    Cardiac channelopathy, or primary cardiac electrical disease indicates myocyte ion channel dysfunction due to encoding ion channel gene and related gene mutation. Channelopathy usually causes the unstable cardiac electrical activity and results in arrhythmia. Brugada syndrome, long QT syndrome and short QT syndrome are three paradigms of congenital cardiac channelopathies in which a single gene mutation causes clinical arrhythmia, syncope and sudden cardiac death (SCD). They are currently the best available channelopathy models for evaluating the relationship between genotype-phenotype and understanding the electrophysiological mechanisms for malignant arrhythmia.Read more.....,