Published on:
    Journal of Cardiovascular Disease Research, 2010; 1(3):99-103
    Invited Review | doi:10.4103/0975-3583.70898

    High density lipoproteins-based therapies for cardiovascular disease


    Dr. Xuan Gao,

    Departments of Physiology and Biophysics, Boston University School of Medicine, 700 Albany St. W302, Boston, MA 02118, USA. E-mail:


    Atherosclerosis is the leading cause of death in developed countries. High density lipoproteins (HDL) cholesterol level correlates inversely with the risk of cardiovascular diseases. Thus, HDL has obtained lots of interest for drug development. In this review, we summarized the mechanisms for the antiatherogenic function of HDL, current HDL-based drugs in clinical use and the future direction for HDL-based therapy development.

    Key words: High density lipoprotein, reverse cholesterol transport, atherosclerosis, drug development