Published on:
    Journal of Cardiovascular Disease Research, 2011; 2(1):57-60
    Original Article | doi:10.4103/0975-3583.78598

    Evaluation of correlation between oxidative stress and abnormal lipid profile in coronary artery disease

    Authors:

    Venkata Rao, Ravi Kiran1

    Department of Biochemistry, Katuri Medical College, Katuri Chinakondrupadu, Guntur - 522 019,Andhra Pradesh.

    1ASRAM Medical College, Eluru, 534 005 Andhra Pradesh, India

    Abstract:

    Background: Coronary artery disease (CAD) is the most common cause of sudden death, and death of men and women over 20 years of age. The aim of the study was to know if there is any linear correlation between oxidants and abnormal lipid profile parameters in CAD. Materials and Methods: The present study includes 42 known CAD cases (age = 41–75 years) and 33 age- and sex-matched healthy controls. Malondialdehyde (MDA), total cholesterol, high-density lipoprotein (HDL) cholesterol, and triacylglyceride were measured and low-density lipoprotein (LDL) cholesterol was calculated in both cases and controls, respectively. Results: MDA was significantly increased in cases than controls (P = 0.0000001). Total cholesterol was high in cases than controls (P = 0.0000001). HDL cholesterol was significantly decreased in cases than controls (P = 0.0000001). LDL cholesterol was high in cases than controls (P = 0.0000001). Triacylglyceride was high in cases than controls (P = 0.0000001). Insignificant positive correlation were observed between MDA and total cholesterol (r = 0.258), between MDA and LDL cholesterol (r = 0.199), and between MDA and HDL cholesterol (r = 0.134). Negative correlation was observed between MDA and triacylglyceride (r = -0.314). Conclusion: Increased oxidative stress and abnormal lipid profile were observed in CAD cases. Our study showed that statistically significant linear relationship could not be established between increased oxidative stress and abnormal lipid profile parameters, suggesting that increased oxidative stress and abnormal lipid profile are two independent risk factors in the pathomechanism of atherogenesis.

    Key words: Abnormal lipid profile, atheromatous plaques, coronary artery, coronary artery disease, myocardium, oxidants