Published on:
    Journal of Cardiovascular Disease Research, 2011; 2(2):91-95
    INVITED REVIEW | doi:10.4103/0975-3583.83033

    The role of endogenous aryl hydrocarbon receptor signaling in cardiovascular physiology


    Nan Zhang

    Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical School, USA


    The aryl hydrocarbon receptor (AHR) is an orphan nuclear receptor with a primary function of mediating xenobiotic metabolism through transcriptional activation of Phase I and Phase II drug-metabolizing enzymes. Although no high-affinity physiological activators of  AHR have been discovered, the endogenous signaling of the AHR pathway is believed to play an important role in the development and function of the cardiachypertophy, abnormal vascular structure in multiple organs and altered blood pressure depending on their host environment. In the review, the endogenous role of AHR in cardiovascular pysiology, inculding heart function,vascular development and blood pressure regulation has been summarized and discussed.

    Key words: Anyl hydrocarbon receptor,blood pressure, cardiac hypertrophy, hypertension, hypotension