Published on:
    Journal of Cardiovascular Disease Research, 2011; 2(1):68-70
    CLINICAL CASE REPORT BASED STUDY | doi:10.4103/0975-3583.78600

    Recurrent strokes under anticoagulation therapy: Sticky platelet syndrome combined with a patent foramen ovale


    A. Gehoff, J. G. Kluge1, P. Gehoff2, D. Jurisch1, D. Pfeifer1, J. Hinz2, A. F. Popov3,4

    Institute of Pathology Nordhessen, Kassel,

    1Department of Internal Medicine I, University Hospital Leipzig, Germany,

    2Department of Anaesthesiology, Emergency and Critical Care Medicine,

    3Department of Thoracic and Cardiovascular Surgery, University of Göttingen, Germany,

    4Department of Cardiothoracic Transplantation and Mechanical Support, Royal Brompton and Harefield Hospitals, London, United Kingdom


    The sticky platelet syndrome (SPS) is a congenital disorder characterized by platelet hyperaggregability to epinephrine and/or adenosine diphosphate; this predisposes affected individuals to acute myocardial infarction, ischemic optic neuropathy, recurrent venous thromboembolism, and transient ischemic cerebral attacks and strokes. Here, we describe an unusual case with recurrent cerebrovascular accidents due to SPS, in the presence of a patent foramen ovale (PFO). We report an unusual case of a 56-year-old female patient with a PFO, who suffered from recurrent strokes despite long-term medication with clopidogrel for SPS. The patient underwent successful transcatheter closure of the PFO, and, in addition, she has been placed on low-dose acetylsalicylic acid. After 18-month follow-up, she demonstrated an intact atrial septum without any vegetations on the percutaneous device until today. She has had no further thromboembolic events.

    Key words: Cryptogenic stroke, patent foramen ovale, sticky platelet syndrome.