Published on:
    Journal of Cardiovascular Disease Research, 2011; 2(2):96-103
    INVITED REVIEW | doi:10.4103/0975-3583.83035

    Inflammation and diabetic retinal microvascular complications


    Wenbo Zhang1,2,3, Hua Liu1,2, Mohamed Al-Shabrawey2,4, Robert W. Caldwell3, Ruth B. Caldwell1,2,5,6,7

    1Vascular Biology Center,

    2Vision Discovery Institute and the

    3Departments of Pharmacology and Toxicology,

    4Oral Biology and Anatomy,

    5Cellular Biology and Anatomy,

    6Ophthalmology, Georgia Health Sciences University, Augusta, Georgia; and the

    7VA Medical Center, Augusta, Georgia, USA.


    Diabetic retinopathy (DR) is one of the most common complications of diabetes and is a lending cause of blindness in people of the working age in Western countries. A major pathology of DR is microvascular complications such as non-perfused vessels,microaneurysms,dot/blot hemorrhages,cotton-woolspots, venousbeading,vascular leakage and neovacularization. Multiple mechanisms are involved in these alternations. This review will focus on the role of inflammation in diabetic retional microvascular complications and discuss the potetial therapies by targeting inflammation.

    Key words: Diabetic retinopathy, inflammation, microvascular complications