Published on:
    Journal of Cardiovascular Disease Research, 2011; 2(3):153-155
    Review Article | doi:10.4103/0975-3583.85261

    Night-time exogenous melatonin administration may be a beneficial treatment for sleeping disorders in beta blocker patients

    Authors:

    Auda Fares

    Department of Internal Medicine, S. Johannes Hospital, Germany

    Abstract:

    Sleep disorders are the common side effects of beta blockers. Beta blockers have been shown to reduce the production of melatonin via specific inhibition of adrenergic beta1-receptors. Exogenous melatonin, taken in the evening as a supplement, could reduce the central nervous system (CNS) side effects (sleep disorder) associated with beta-adrenergic receptor blockers as well as the potential risk associated with reduction of the melatonin synthesis.

    Key words: Beta blockers, hypertension, melatonin