Published on:
    Journal of Cardiovascular Disease Research, 2012; 3(1):03-04
    Commentary | doi:10.1016/S0975-3583(12)31002-4

    Athero-protective actions of two oral antidiabetic drugs: Suppression of inflammation and oxidative stress


    Kan Chen

    Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women’s Hospital, Boston, USA


    Diabetes mellitus increases the risk and accelerates the clinical course of atherosclerosis, and is responsible for majority of the deaths and disabilities in type 2 diabetic population.[1] Optimal strategies to prevent the onset or progression of atherosclerosis will improve the clinical outcome of this high-risk population. In the current study, the research team showed that two antidiabetic agents, namely Glimepiride and Repaglinide, prevent the progression of atherosclerosis in high fat diet fed rabbits, by exerting their anti-inflammatory and anti-oxidate effects.Read more....,