Published on:
    Journal of Cardiovascular Disease Research, 2011; 2(4):241-243
    CLINICAL CASE REPORT BASED STUDY | doi:10.4103/0975-3583.89810

    Accelerated atherosclerosis in a human immunodeficiency virus infected patient not on highly active anti-retroviral therapy: An autopsy case report

    Authors:

    R Kalyani1, MJ Thej1, K Prabhakar2, J Kiran3

    1 Department of Pathology, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India

    2 Department of Medicine, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India

    3 Department of Forensic Medicine, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India

    Abstract:

    The pandemic spread of human immunodeficiency virus (HIV) has been the greatest challenge to public health in modern times. However today, people infected with HIV are living longer due to highly active antiretroviral therapy (HAART). This has resulted in age related complications like cardiovascular diseases, causing increased morbidity and mortality. The relative contributions of HIV infection versus potential adverse effects of HAART to coronary heart disease risk remains unclear. Recent reports implicate both HIV infection per se and HAART therapy to cause metabolic derangements which are pro-atherogenic. Here, we report a case of HIV infected young patient never exposed to HAART, presenting with accelerated atherosclerosis in aorta, coronary and carotid arteries.

    Key words: Accelerated atherosclerosis, autopsy, highly active anti-retroviral therapy, human immunodeficiency virus.