Published on:
    Journal of Cardiovascular Disease Research, 2013; 4(1):3-6
    Original Article | doi:10.1016/j.jcdr.2012.08.004

    Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome


    Wen Ni Tiong a,b,*, Edmund Ui Hang Sim b, Alan Yean Yip Fong a,c, Tiong Kiam Ong c

    a Clinical Research Centre, Sarawak General Hospital, Malaysia

    b Faculty of Resource Science and Technology, University Malaysia Sarawak, Kota Samarahan, Malaysia

    c Department of Cardiology, Sarawak General Hospital, Kuching, Malaysia


    Background: Diagnosing acute coronary syndrome (ACS) remains a challenge in patients presenting at early phase of hospitalization. We hypothesized that inflammatory markers of plaque rupture could accurately identifying ACS patients from stable coronary artery diseases (CAD). Materials and methods: The serum and peripheral blood gene expression levels of C-reactive protein (CRP) and von Willebrand factor (vWF) in multiethnic Malaysian patients (n = 7) admitted with early hospitalization of ACS was evaluated. Nine patients with stable coronary artery disease without previous history of ACS were enrolled as controls. Results: Serum and peripheral blood mRNA levels of CRP and vWF were significantly higher in ACS compared to control groups (P < 0.05). Conclusions: Elevated levels of these markers in ACS may reflect an acute phase response due to endothelial dysfunction. Both CRP and vWF may add to the list of useful markers for early detection of ACS in hospitals of developing countries.

    Key words: Acute coronary syndrome, C-reactive protein, von Willebrand factor.