Published on:12-2014
    Journal of Cardiovascular Disease Research, 2014; 5(4):22-27
    Original Article | doi:10.5530/jcdr.2014.4.5

    Novel Biomarkers in Assessing Cardiovascular Status in Acute Myocardial Infarction

    Authors:

    Qazi Najeeb*1, Sajad Hamid2 Ather Hafiz Khan3

    1Post M.D Demonstrator, Department of Biochemistry, SKIMS Medical College Bemina, Srinagar, India.

    2Lecturer Anatomy, SKIMS Medical College, Bemina, Srinagar, India.

    3Post D. N. B Demonstrator, Department of Pathology, SKIMS Medical College Bemina, Srinagar, India.

    Abstract:

    The article is now marked as retracted from the journal, read retraction notice in Oct-Dec, 2015 Issue

    Introduction: The traditional risk factors for coronary heart disease do not account for the entirety of risk and there are many people who have events who do not fit into these the traditional risk factors. Aim: To assess multiple biomarkers representing in relation to cardiovascular events and to evaluate the levels of HbA1c, sialic acid, Homocysteine, high sensitive C–reactive protein in non-diabetic individual with acute myocardial infarction and possibility of their use as markers for coronary vascular events. Methods: Total 600 patients were included in the study and were divided into two groups: Group-I (cases): 300 clinically diagnosed non-diabetic myocardial infarction patients admitted in Emergency and ICCU wards. Group-II (controls): age and sex matched 300 healthy subjects with no history of diabetes mellitus and/or myocardial infarction were included. The blood samples were collected from all the cases and the control and were immediately analyzed for biochemical parameters under the study. Results: The result indicates that there is a statistically significant increase in Systolic-BP, Diastolic-BP, fasting blood glucose, HbA1c, LDL-C, sialic acid, homocysteine and Hs-CRP levels in cases as compared to control group (<0.001). Also, there is a direct and significant correlation between sialic acid with homocysteine, Hs-CRP and HbA1c respectively (r =0.24, 0.24, 0.30, p<0.05). HbA1c showed significantly positive correlation with homocysteine, Hs-CRP and Diastolic-BP (r = 0.27, 0.24 and 0.19) respectively and had negative correlation (r = -0.20) with HDL-C. Statistically, significant positive correlation of homocysteine and Hs-CRP was seen with each other (r = 0.29, p = 0.00) and with rest of the parameters, except with HDL-C which showed negative but significant correlation. Conclusion: As the concentrations of these cardiac biomarkers are increased in non-diabetic AMI subjects, it isrecommended that HbA1c, sialic acid, homocysteine and high sensitive C–reactive protein should also be included in the growing armament of biochemical cardiovascular disease markers for a better, early and more objective assessment of the disease.

    Keywords: Cardiovascular diseases,Myocardial infarction, HbA1c, Sialic acid, Homocysteine, High sensitive C–reactive protein.