Published on:1
    Journal of Cardiovascular Disease Research, 2014; 5(4):15-21
    Original Article | doi:10.5530/jcdr.2014.4.4

    Levels of thyroid hormone, ferritin and testosterone in Acute Myocardial Infarction (AMI) patients in north India

    Authors:

    Atreyee Basu1, Shashi Seth2, Kanchan Arora3, Nupur Bansal4

    1Senior Resident, Dept of Biochemistry, PGIMS, Rohtak, Haryana, India.

    2Senior Professor, Dept of BicoChemistry, PGIMS, Rohtak, Haryana, India.

    3Senior Resident, Dept of BicoChemistry, VMMC and Safolarjung Hospital, New Delhi.

    4Senior Resident, Dept of Radio Therapy, PGIMS, Rohtak, Haryana, India.

    Abstract:

    Background: Thyroid hormone plays a critical role in cardiomyocyte maturation and stress-related cellular responses like AMI. The inhibition of thyroid hormone receptor alfa (TRα) causes down regulation of this hormone in post-ischemic myocardium. On the other hand, ferritin, an inflammatory marker; and testosterone, a hormone which alters lipid profile, also play significant roles in pathogenesis of AMI. The objective of our study was to compare thyroid profile (total T3, T4 and TSH), ferritin, Vitamin B-12, folic acid and testosterone in newly diagnosed male cases of AMI with age-matched controls. We also contrasted these biochemical parameters between AMI subgroups with very low and low left ventricular ejection fraction (LVEF). Methodology: A cross-sectional study was conducted from September, 2012 to February, 2013 at a tertiary care hospital of north India. Newly diagnosed male AMI patients with positive clinical and ECG findings, and CPK MB > 25 U/L (spcetrophotometric method) and Troponin-I ultra > 2ng/ml (chemiimmunofluroscence method) were enrolled as cases (n=43). Cases were further sub-classified into those with very low LVEF (<35%, Group 1) and low LVEF (35-50%, Group 2). Serum was pooled at 12-24 hr of onset of symptoms and preserved at -20°C until analyzed. Serum TSH was measured with immunoradiometric assay; serum T3 and T4 were measured with radioimmuno assay. Serum ferritin, Vitamin B-12, folic acid and testosterone were also estimated (chemiimmunofluroscence method) in all cases. 40 age and sex matched controls were similarly examined. Result: AMI patients reported significantly lower T3, higher ferritin and lower testosterone level in comparison to control group. On the other hand, cases with lower LVEF (<35%) showed significantly lower value of CPK MB, T3, ferritin and testosterone. Conclusion: Our study found down regulation of T3 and testosterone levels, with raised higher ferritin levels in patients suffering from an acute attack of AMI.

    Key words: AMI, Thyroid hormone, Ferritin, Testosterone.

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