Background: Prevalence of several cardio metabolic risk factors, especially central obesity and dyslipidemia, places women in high risk group for development of insulin resistance and atherosclerosis. Physiological and hormonal in women acts as an additional risk factor for such disease. The burden of cardio metabolic risk in middle aged pre-menopausal women need to evaluated thoroughly. Objective: The study was designed to assess cardio metabolic risk profile and to evaluate association of traditional risk factors of metabolic syndrome with obesity and atherogenic markers in middle aged pre-menopausal Indian women. Materials and Methods: One hundred and thirty seven randomly selected female subjects ( age 25-45 years) were evaluated for prevalence of various cardio metabolic risk factors. The parameters studied included body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), blood pressure, ECG, fasting blood glucose level and lipid profile of the subject. The association between various traditional risk factors of metabolic syndrome and the obesity and atherogenic markers of the subject was evaluated. Results: The overall prevalence rate of metabolic syndrome in middle aged pre-menopausal women was found to be 28.99%. The rate of incidence of metabolic syndrome increases with advancement of age. The most common individual component of metabolic syndrome in subject was central obesity followed by altered lipid profile. All the traditional risk factors of metabolic syndrome were found to very with WC, WHR and TG/HDL-C ratio of the subject. Conclusion: The result of the present study suggest that central obesity followed by altered lipid profile are the main causative factors for development of metabolic syndrome in pre-menopausal middle aged Indian women. Obesity markers like waist circumference and waist –hip ratio and TG/HDL-C ratio can be used to predict metabolic syndrome in this group of subjects.
Key words: Metabolic syndrome, Premenopausal women, TG/HDL-C, WC, WHR.