Published on:2nd May 2015
    Journal of Cardiovascular Disease Research, 2015; 6(2):67-71
    Original Article | doi:10.5530/jcdr.2015.2.4

    Cardiovascular Risk Factors Insulin Resistance [IR], High Sensitivity C-reactive Protein (hs-CRP) and Fibrinogen in Pre-Menopausal women with Poly cystic ovarian syndrome (PCOS)

    Authors:

    Praveen Sharma1, Aditi Gupta2, Purvi Purohit3*

    1Professor & Head, Department of Biochemistry, AIIMS Jodhpur, India.

    2Department Biochemistry, SMS Jaipur, India.

    3Assistant Professor, Department of Biochemistry, AIIMS Jodhpur, India.

    Abstract:

    Polycystic ovarian syndrome (PCOS) is one of the commonest endocrine pathies in women of reproductive age. We aimed to establish cardiovascular (CVD) risk factors in pre-menopausal Indian women with PCOS. Methods and Results: Study included 150 women (100 PCOS and 50 controls) from reproductive age (25-45 years). Both study groups were examined and analysed for anthropometric, clinical and biochemical parameters. Observations were subjected to statistical analysis using the descriptive statistics, Pearson’s coefficient of correlation and Multiple regression analysis. PCOS women presented with central adiposity (Waist circumference (cms) - 85.82 ± 12.16 v/s 78.84 ± 9.66p<0.001), hypertension(mm of Hg) (Systolic blood pressure- 130.89 ± 7.63 v/s 123.3 ± 8.02; Diastolic blood pressure- 87.56 ± 5.77 v/s 83.14 ± 6.38 p<0.001), insulin resistance (IR) (6.99 ± 3.10 v/s 4.73 ± 3.66 p<0.001), hyperinsulinemia (μIU/ml) (29.02 ± 8.85 v/s 19.46 ± 10.80 p<0.001), dyslipidemia and raised luteinizing hormone (LH)(IU/L) (7.52 ± 2.39 v/s 6.18 ± 1.29 p<0.001), fibrinogen (mg/ dl) (215.7 ± 58.87 v/s 182.3 ± 14.61 p<0.001) and high sensitivity C-reactive protein(hs-CRP) (mg/L) (2.27 ± 0.95 v/s 2.17 ± 0.30 p<0.001) as compared to healthy control women.66% PCOS women had metabolic syndrome (MS). Strong association of central adiposity with serum insulin (r=0.22; p=0.007) and IR with body mass index [BMI], Waist to Hip ratio, hypertension, fibrinogen and hs-CRP was observed. IR (p<0.005) was strongest CVD risk factor in these women (p<0.001). Conclusion: Obesity, IR, high pro-thrombotic and pro-inflammatory factors in Indian PCOS women indicate strong CVD risk and could cause cardiovascular complications in later life.

    Key words: Dyslipidemia, fibrinogen, HDL2c, hs-CRP, Insulin resistance, PCOS, sd LDLc.

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