Background: Obesity is one of the most common health problems in developed and developing nations like India. In addition, obesity is considered as a principal risk factor in the initiation of various non communicable chronic diseases such as dyslipidemia, atherosclerosis, cardiovascular, non-insulin dependent diabetes mellitus etc. The pathogenesis of these diseases is associated with oxygen-derived free radicals. Aim: The aim of the study was to analyze oxidative status in obese subjects with respect to normal healthy subjects. Material and Methods: The present study was performed in 50 obese men (BMI>46 kg/m2) and equal number of normal healthy men (BMI< 27 kg/m2) and the levels of malondialdehyde, antioxidant enzymes/molecules like superoxide dismutase, catalase reduced glutathione, glutathione reductase, glutathione peroxidase, antioxidant Vitamin-E and Vitamin-C along with total antioxidant activity were evaluated. Results: A significant increase (p<0.01) in the concentration of malondialdehyde by 61.07% was observed in obese men subjects in comparison to normal healthy men subjects while a significant fall was recorded in the levels of vitamin-E (19.54%, p<0.05), Vitamin-C (18.07%, p<0.05), superoxide dismutase (19.51%, p<0.05), catalase (20.28%, p<0.05), GSH (36.56%, p<0.05), GR (33.28%, p<0.01), GPx (19.14%, p<0.05) and a significant decrease by 33.33% (p<0.01) was observed in the total antioxidant activity in obese subjects as compared to normal healthy control subjects. Conclusion: Aforementioned observations suggested that oxidative is induced in the obese subjects (BMI>46 kg/m2) due to alterations in the malondialdehyde and other oxidative stress markers such as Vitamin-E, Vitamin-C, Superoxide dismutase, catalase, reduced glutathione, glutathione reductase and glutathione peroxidase might be responsible for the etiology of diseases like diabetes, cancer arthritis, atherosclerosis etc. and therefore, obesity should be treated with the same attention of noncommunicable diseases like atherosclerosis, arthritis, diabetes, cancer etc.
Key words: Obesity, Oxidative stress, Vitamin-E, Vitamin-C, Lipoproteins, Lipid peroxidation, Antioxidants, Cardiovascular disease (CVD).