Published on:January 2016
    Journal of Cardiovascular Disease Research, 2016; 7(1):16-22
    Original Article | doi:10.5530/jcdr.2016.1.2

    Atherosclerosis in the age group of less than 30 years in relation to panniculous fat thickness: An autopsy analysis

    Authors:

    D. R. Mahadeshwara Prasad,1 Vijayalaxmi V. Suranagi,2 Ajay Kumar S,3 Prasanna S Jirli4

    1Department of Forensic Medicine & Toxicology, District Hospital (Ministry of Health & Family Welfare, Government of Karnataka), and Assistant professor, Department of Forensic Medicine & Toxicology, Chamarajanagar Institute of Medical Sciences, Chamarajanagar, Karnataka, INDIA.

    2Department of Pathology, Jawaharlal Nehru Medical College, Belgaum, Karnataka, INDIA.

    3Department of Forensic Medicine & Toxicology, Koppal Institute of Medical Sciences, Koppal, Karnataka, INDIA.

    4Department of Forensic Medicine & Toxicology, Jawaharlal Nehru medical College, Belgaum, Karnataka, INDIA.

    Abstract:

    Introduction: Non-communicable diseases (NCD) are a clear threat not only to human health, but also to development and economy. Fatalities due to chronic non-communicable diseases occur in prime of productive life. Coronary heart disease such as angina pectoris, myocardial infarction or sudden death due to coronary thrombosis is well known NCD which is mainly due to atherosclerosis. Information about the start of an atherosclerotic process in arterial wall, as well as various stages of atherosclerosis and the relationship of risk factors is evident from autopsy studies, as living subjects can provide information about lesions when they are quite advanced. Thus, the information gathered from autopsies in this study will assess the earliest age at which atherosclerotic process starts to occur and age by age progression of the process. Methodology: A cross-sectional pathobiology study of atherosclerosis was conducted among 40 apparently normal individuals within the age group of 30 years who died accidentally were included in the study (28 males and 12 females; mean age, 22.42 years) The histopathological report was tabulated and analyzed with respect to age and life style. Age related progress in atherosclerosis was assessed in correlation of panniculus fat thickness. Results: The results were based on macroscopic and microscopic appearance of atherosclerotic changes. The earliest age at which microscopic atherosclerotic change was seen at 7 years of age and the earliest macroscopic changes was seen at 17 years of age. Most of the subjects under 30 years of age showed fatty streaks, the precursors to develop advanced plaques. Among the risk factors smoking, obesity, and alcohol consumption surpass the others. Conclusion: In stratification of risk, and in monitoring the effects of intervention in obese children with non manifesting clinical atherosclerotic cardiovascular disease, assessment of the subclinical markers of atherosclerosis may help in the evaluation of the progression of atherosclerosis. The assignment of a “vascular age,” may be a useful method to quantify the “end organ” effects of exposure to these various risks. Broad social, cultural, legislative and policy changes that support healthy lifestyles within families and communities need to be implemented to decrease the prevalence of childhood obesity and its cardiovascular consequences in communities.

    Key words: Atherosclerosis, Panniculous fat, Dyslipidemias, Non-communicable diseases, Smoking, Tobacco chewing, Alcohol, Junk food.

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