Published on:September 2016
    Journal of Cardiovascular Disease Research, 2016; 7(3):116-119
    Original Article | doi:10.5530/jcdr.2016.3.4

    Investigation of P-Wave Dispersion in Adult Patients with Beta-Thalassemia Major


    Sajad Amirghofran1, Amir Aslani2, Maryam Zakerinia3

    1International branch, Shiraz University of Medical Sciences, Shiraz, IRAN.

    2Cardiology Department, Shiraz University of Medical Sciences, Shiraz, IRAN.

    3Department of Internal Medicine, Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, IRAN.


    Background: Paroxysmal atrial tachyarrhythmias, especially atrial fibrillation is a fatal complication that occur more frequently in patients with β-thalassemia major (β-TM) than normal population. This study aimed to compare P-wave dispersion (PWD) in patients with β-thalassemia major with control subjects for the early prediction of arrhythmia risk. Methods: Sixty-six adult patients with β-TM referring to Shahid Motahari hospital of Marvdasht in winter 2015 were compared to 50 non-thalassemic adults. All participants underwent routine 12-leads electrocardiography (ECG) for cardiac evaluation. ECGs were scanned and PWD was calculated as the difference between the maximum and the minimum P-wave duration. Results: Patients with β-TM aged between 18 to 47 years old and were matched by age and gender to the control group. There was a statistically significant difference between the study and control groups in minimum P-wave duration (44.8±9.8 vs 49.1±5.3 ms, p=0.006), maximum P-wave duration (105.3±12.5 vs 97.6±6.4 ms, p<0.001) and PWD (60.5±11.00 vs 48.6±7.8 ms, p<0.001). Conclusion: PWD increased in β-TM patients, thus, these patients should be closely followed up for risk of atrial fibrillation which can be life threatening.

    Key words: Electrocardiography, PWD, beta-Thalassemia, Atrial Fibrillation, Iron Overload.

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